@Article{IPB-1453,
author = {van Berkel, S. S. and Brauch, S. and Gabriel, L. and Henze, M. and Stark, S. and Vasilev, D. and Wessjohann, L. A. and Abbas, M. and Westermann, B.},
title = {{Traceless Tosylhydrazone-Based Triazole Formation: A Metal-Free Alternative to Strain-Promoted Azide-Alkyne Cycloaddition}},
year = {2012},
pages = {5343-5346},
journal = {Angew. Chem. Int. Ed.},
doi = {10.1002/anie.201108850},
volume = {51},
abstract = {Triple‐T trick! Traceless tosylhydrazone‐based triazole formation is readily achieved by reacting primary amines with functional α,α‐dichlorotosylhydrozones under ambient conditions. This fast and efficient alternative affords exclusively 1,4‐substituted triazole “click products” with complete retention of configuration. Primary amines, inherent to many natural products, can be modified in this way without protecting group manipulations.}    
}