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Publications - Molecular Signal Processing

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Displaying results 1 to 10 of 48.

Publications

Quint, M.; Melchinger, A.E.; Dussle, C.M.; Lübberstedt, T. Breeding for virus resistance in maize Genetika 32, 283-291, (2000)

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Dussle, C.M.; Quint, M.; Xu, M.L.; Melchinger, A.E.; Lübberstedt, T. Conversion of AFLP fragments tightly linked to Scmv1 and Scmv2 into simple PCR-based markers Theor Appl Genet 105, 1190-1195, (2002)

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Publications

Quint, M.; Mihaljevic, R.; Dussle, C.M.; Xu, M.L.; Melchinger, A.E.; Lübberstedt, T. Development of RGA-CAPS markers and genetic mapping of candidate genes for SCMV resistance in maize Theor Appl Genet 105, 355-366, (2002)

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Publications

Dussle, C.M.; Quint, M.; Xu, M.L.; Melchinger, A.E.; Lübberstedt, T. Saturation of two chromosome regions conferring resistance to SCMV with SSR and AFLP markers by targeted BSA Theor Appl Genet 106, 485-493, (2003)

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Publications

Quint, M.; Dussle, C.M.; Melchinger, A.E.; Lübberstedt, T. Identification of genetically linked RGAs by BAC screening in maize and implication for gene cloning, mapping, and MAS Theor Appl Genet 106, 1171-1177, (2003)

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Publications

Frisch, M.; Quint, M.; Lübberstedt, T.; Melchinger, A.E. Duplicate marker loci can result in incorrect locus orders on linkage maps Theor Appl Genet 109, 305-316, (2004)

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Quint, M.; Ito, H.; Zhang, W.; Gray, W.M. Characterization of a novel temperature-sensitive allele of the CUL1/AXR6 subunit of SCF ubiquitin-ligases Plant J 43, 371-383, (2005)

Selective protein degradation by the ubiquitin-proteasome pathway has emerged as a key regulatory mechanism in a wide variety of cellular processes. The selective components of this pathway are the E3 ubiquitin-ligases which act downstream of the ubiquitin-activating and -conjugating enzymes to identify specific substrates for ubiquitinylation. SCF-type ubiquitin-ligases are the most abundant class of E3 enzymes in Arabidopsis. In a genetic screen for enhancers of the tir1-1 auxin response defect, we identified eta1/axr6-3, a recessive and temperature-sensitive mutation in the CUL1 core component of the SCFTIR1 complex. The axr6-3 mutation interferes with Skp1 binding, thus preventing SCF complex assembly. axr6-3 displays a pleiotropic phenotype with defects in numerous SCF-regulated pathways including auxin signaling, jasmonate signaling, flower development, and photomorphogenesis. We used axr6-3 as a tool for identifying pathways likely to be regulated by SCF-mediated proteolysis and propose new roles for SCF regulation of the far-red light/phyA and sugar signaling pathways. The recessive inheritance and the temperature-sensitive nature of the pleiotropically acting axr6-3 mutation opens promising possibilities for the identification and investigation of SCF-regulated pathways in Arabidopsis.
Publications

Quint, M.; Gray, W.M. Auxin signaling Curr Opin Plant Biol 9, 448-453, (2006) DOI: 10.1016/j.pbi.2006.07.006

Auxin regulates a host of plant developmental and physiological processes, including embryogenesis, vascular differentiation, organogenesis, tropic growth, and root and shoot architecture. Genetic and biochemical studies carried out over the past decade have revealed that much of this regulation involves the SCFTIR1/AFB-mediated proteolysis of the Aux/IAA family of transcriptional regulators. With the recent finding that the TRANSPORT INHIBITOR RESPONSE1 (TIR1)/AUXIN SIGNALING F-BOX (AFB) proteins also function as auxin receptors, a potentially complete, and surprisingly simple, signaling pathway from perception to transcriptional response is now before us. However, understanding how this seemingly simple pathway controls the myriad of specific auxin responses remains a daunting challenge, and compelling evidence exists for SCFTIR1/AFB-independent auxin signaling pathways.
Books and chapters

Quint, M.; Lübberstedt, T. Application of resistance gene analogs in breeding for virus resistance (Rao, GP, Valverde, RA, Christomas, D.). Techniques in Diagnosis of Plant Viruses. Studium Press LLC, USA 267-287, (2008)

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Publications

Delker, C.; Raschke, A.; Quint, M. Auxin dynamics: the dazzling complexity of a small molecule's message Planta 227, 929-941 , (2008) DOI: 10.1007/s00425-008-0710-8

The phytohormone auxin is a potent regulator of plant development. Since its discovery in the beginning of the twentieth century many aspects of auxin biology have been extensively studied, ranging from biosynthesis and metabolism to the elucidation of molecular components of downstream signaling. With the identification of the F-box protein TIR1 as an auxin receptor a major breakthrough in understanding auxin signaling has been achieved and recent modeling approaches have shed light on the putative mechanisms underlying the establishment of auxin gradients and maxima essential for many auxin-regulated processes. Here, we review these and other recent advances in unraveling the entanglement of biosynthesis, polar transport and cellular signaling events that allow small auxinic molecules to facilitate their complex regulatory action.
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