Publications - Molecular Signal Processing
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Displaying results 1 to 1 of 1.
Gasperini, D.; Chételat, A.; Acosta, I. F.; Goossens, J.; Pauwels, L.; Goossens, A.; Dreos, R.; Alfonso, E.; Farmer, E. E. Multilayered Organization of Jasmonate Signalling in the Regulation of Root Growth PLOS Genet 11, e1005300, (2015) DOI: 10.1371/journal.pgen.1005300
Physical damage can strongly affect plant
growth, reducing the biomass of developing organs situated at a distance
from wounds. These effects, previously studied in leaves, require the
activation of jasmonate (JA) signalling. Using a novel assay involving
repetitive cotyledon wounding in Arabidopsis seedlings, we uncovered a
function of JA in suppressing cell division and elongation in roots.
Regulatory JA signalling components were then manipulated to delineate
their relative impacts on root growth. The new transcription factor
mutant myc2-322B was isolated. In vitro transcription assays and
whole-plant approaches revealed that myc2-322B is a dosage-dependent
gain-of-function mutant that can amplify JA growth responses. Moreover,
myc2-322B displayed extreme hypersensitivity to JA that totally
suppressed root elongation. The mutation weakly reduced root growth in
undamaged plants but, when the upstream negative regulator NINJA was
genetically removed, myc2-322B powerfully repressed root growth through
its effects on cell division and cell elongation. Furthermore, in a
JA-deficient mutant background, ninja1 myc2-322B still repressed root
elongation, indicating that it is possible to generate JA-responses in
the absence of JA. We show that NINJA forms a broadly expressed
regulatory layer that is required to inhibit JA signalling in the apex
of roots grown under basal conditions. By contrast, MYC2, MYC3 and MYC4
displayed cell layer-specific localisations and MYC3 and MYC4 were
expressed in mutually exclusive regions. In nature, growing roots are
likely subjected to constant mechanical stress during soil penetration
that could lead to JA production and subsequent detrimental effects on
growth. Our data reveal how distinct negative regulatory layers,
including both NINJA-dependent and -independent mechanisms, restrain JA
responses to allow normal root growth. Mechanistic insights from this
work underline the importance of mapping JA signalling components to
specific cell types in order to understand and potentially engineer the
growth reduction that follows physical damage.