Publications - Cell and Metabolic Biology
Search narrowed by
Advanced Search
- Type of publication
- Publication (2)
- Year
- Journal / Volume / Preprint Server Sorted by frequency and by alphabetical order
- Phytochemistry (52)
- Plant J. (36)
- Planta (32)
- Plant Physiol. (28)
- 0 (19)
- J. Exp. Bot. (15)
- Plant Cell (14)
- Methods Mol. Biol. (13)
- New Phytol. (13)
- FEBS Lett. (12)
- J. Plant Physiol. (12)
- PLOS ONE (11)
- Front. Plant Sci. (10)
- Plant Cell Physiol. (9)
- bioRxiv (9)
- Int. J. Mol. Sci. (8)
- Mycorrhiza (8)
- J. Biol. Chem. (7)
- Plant Mol. Biol. (6)
- Biologie in unserer Zeit (5)
- Mol. Plant (5)
- Plant Cell Environ. (5)
- Plants (5)
- Trends Plant Sci. (5)
- BMC Plant Biol. (4)
- J. Agr. Food Chem. (4)
- Plant Biotechnol. J. (4)
- Plant Sci. (4)
- Plant Signal Behav. (4)
- Anal. Biochem. (3)
- Bot. Acta (3)
- Plant Biol. (3)
- Plant Growth Regul. (3)
- ACS Synth. Biol. (2)
- Adv. Exp. Med. Biol. (2)
- Anal. Bioanal. Chem. (2)
- Biotechnol. J. (2)
- Commun. Biol. (2)
- Environ. Exp. Bot. (2)
- Lecture Notes in Computer Science (2)
- Metab. Eng. (2)
- Methods Enzymol. (2)
- Mol. Plant Microbe Interact. (2)
- Nat. Commun. (2)
- Physiol. Mol. Plant Pathol. (2)
- Plant Meth. (2)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Sci. Rep. (2)
- Theor. Appl. Genet. (2)
- ACS Chem. Biol. (1)
- Acta Biol. Szeged. (1)
- Acta Neuropathol. (1)
- Anal. Chem. (1)
- Angew. Chem. (1)
- Angew. Chem. Int. Ed. (1)
- Ann. Appl. Biol. (1)
- Ann. Bot. (1)
- Appl. Environ. Microbiol. (1)
- Atmos. Chem. Phys. (1)
- BIOspektrum (1)
- BMC Biol. (1)
- Biochemistry (1)
- Biochimie (1)
- Bioengineered (1)
- Biol. Chem. (1)
- Biol. Commun. (1)
- Carotenoids: Carotenoid and apocarotenoid biosynthesis metabolic engineering and synthetic biology (1)
- Cereal Res. Commun. (1)
- ChemCatChem (1)
- Chin. J. Anal. Chem. (1)
- Chin. J. Chromatogr. (1)
- Crit. Rev. Plant Sci. (1)
- Curr. Opin. Biotech. (1)
- Curr. Opin. Plant Biol. (1)
- Curr. Protoc. Mol. Biol. (1)
- Dev. Biol. (1)
- EMBO J. (1)
- Environ. Microbiome (1)
- Enzyme Microb. Technol. (1)
- Eur. Food Res. Technol. (1)
- Eur. J. Biochem. (1)
- FASEB J. (1)
- FEBS J. (1)
- Fett/Lipid (1)
- Front. Microbiol. (1)
- Front. Neurosci. (1)
- Funct. Integr. Genomics (1)
- Funct. Plant Biol. (1)
- Genome Biol. (1)
- Int. J. Biol. Macromol. (1)
- J. Adv. Res. (1)
- J. Bacteriol. (1)
- J. Biomed. Mater. Res. B (1)
- J. Chem. Ecol. (1)
- J. Mass Spectrom. (1)
- J. Membr. Sci. (1)
- J. Mol. Biol. (1)
- J. Nat. Prod. (1)
- Mol. Breed. (1)
- Mol. Plant Pathol. (1)
- Author Sorted by frequency and by alphabetical order
- Bouwmeester, H. (2)
- Fraser, P. D. (2)
- Kayser, O. (2)
- Martens, S. (2)
- Staniek, A. (2)
- Tissier, A. (2)
- Warzecha, H. (2)
- Wessjohann, L. (2)
- van der Krol, S. (2)
Displaying results 1 to 2 of 2.
Staniek, A.; Bouwmeester, H.; Fraser, P. D.; Kayser, O.; Martens, S.; Tissier, A.; van der Krol, S.; Wessjohann, L.; Warzecha, H.; Natural products - learning chemistry from plants Biotechnol. J. 9, 326-336, (2014) DOI: 10.1002/biot.201300059
Plant natural products (PNPs) are unique in that they represent a vast array of different structural features, ranging from relatively simple molecules to very complex ones. Given the fact that many plant secondary metabolites exhibit profound biological activity, they are frequently used as fragrances and flavors, medicines, as well as industrial chemicals. As the intricate structures of PNPs often cannot be mimicked by chemical synthesis, the original plant providers constitute the sole source for their industrial, large‐scale production. However, sufficient supply is not guaranteed for all molecules of interest, making the development of alternative production systems a priority. Modern techniques, such as genome mining and thorough biochemical analysis, have helped us gain preliminary understanding of the enzymatic formation of the valuable ingredients in planta. Herein, we review recent advances in the application of biocatalytical processes, facilitating generation of complex PNPs through utilization of plant‐derived specific enzymes and combinatorial biochemistry. We further evaluate the options of employing heterologous organisms harboring PNP biosynthetic pathways for the production of secondary metabolites of interest.
Staniek, A.; Bouwmeester, H.; Fraser, P. D.; Kayser, O.; Martens, S.; Tissier, A.; van der Krol, S.; Wessjohann, L.; Warzecha, H.; Natural products - modifying metabolite pathways in plants Biotechnol. J. 8, 1159-1171, (2013) DOI: 10.1002/biot.201300224
The diversity of plant natural product (PNP) molecular structures is reflected in the variety of biochemical and genetic pathways that lead to their formation and accumulation. Plant secondary metabolites are important commodities, and include fragrances, colorants, and medicines. Increasing the extractable amount of PNP through plant breeding, or more recently by means of metabolic engineering, is a priority. The prerequisite for any attempt at metabolic engineering is a detailed knowledge of the underlying biosynthetic and regulatory pathways in plants. Over the past few decades, an enormous body of information about the biochemistry and genetics of biosynthetic pathways involved in PNPs production has been generated. In this review, we focus on the three large classes of plant secondary metabolites: terpenoids (or isoprenoids), phenylpropanoids, and alkaloids. All three provide excellent examples of the tremendous efforts undertaken to boost our understanding of biosynthetic pathways, resulting in the first successes in plant metabolic engineering. We further consider what essential information is still missing, and how future research directions could help achieve the rational design of plants as chemical factories for high‐value products.