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22.05.2020

+++ News Ticker Science #40 +++ Cyclic peptides +++

Insights into the secondary structures of lactam N-substituted stapled peptides

IPB chemists together with collaborators from the MLU Halle and the University of Havana have taken a closer look at features of a special class of cyclopeptides. Their results were recently published in Organic & Biomolecular Chemistry. This special class of cyclopeptides forms when generating stapled peptides through Ugi macrocyclization. They exhibit an N-substituted lactam bridge cross-linking two amino acid side chains. The researchers report a comprehensive analysis of the structural factors influencing the secondary structure of these cyclic peptides in solution. Furthermore, the authors reveal novel insights into the s-cis/s-trans isomerism and the effect of N-functionalization on the conformation.

Publication:
A. V. Vasco, C. G. Moya, S. Gröger, W. Brandt, J. Balbach, C. S. Pérez, L. A. Wessjohann and D. G. Rivera. Insights into the secondary structures of lactam N-substituted stapled peptides, Org Biomol Chem, 2020, Advance Article, DOI: 10.1039/D0OB00767F

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