+++ News Ticker Science #40 +++ Cyclic peptides +++
Insights into the secondary structures of lactam N-substituted stapled peptides
IPB chemists together with collaborators from the MLU Halle and the University of Havana have taken a closer look at features of a special class of cyclopeptides. Their results were recently published in Organic & Biomolecular Chemistry. This special class of cyclopeptides forms when generating stapled peptides through Ugi macrocyclization. They exhibit an N-substituted lactam bridge cross-linking two amino acid side chains. The researchers report a comprehensive analysis of the structural factors influencing the secondary structure of these cyclic peptides in solution. Furthermore, the authors reveal novel insights into the s-cis/s-trans isomerism and the effect of N-functionalization on the conformation.
A. V. Vasco, C. G. Moya, S. Gröger, W. Brandt, J. Balbach, C. S. Pérez, L. A. Wessjohann and D. G. Rivera. Insights into the secondary structures of lactam N-substituted stapled peptides, Org Biomol Chem, 2020, Advance Article, DOI: 10.1039/D0OB00767F