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11.02.2020

+++ News Ticker Science #27 +++ Therapeutic Targets +++

Glucagon and Glucagon-like Peptide-1 Receptors: Promising Therapeutic Targets

Hidayat Hussain, guest researcher at IPB, together with partners from Oman, has published a review article on the structural diversity of glucagon and glucagon-like protein (GLP)-1 receptors and their signaling pathways. Both receptors play a major role in the maintenance of normal glucose levels in the blood. The authors shed light on site-directed mutations at the receptors and their significance in drug discovery against type-2 diabetes. According to the authors, the use of various agonists and antagonists allowed first insights into the structure-activity relationships (SAR) of the receptors. A better understanding of SAR is required to develop new therapeutic approaches for the diabetes treatment.

Reference:
Abbas, G., Haq, Q.M.I., Hamaed, A., Al-Sibani, M. & Hussain, H. Glucagon and Glucagon-like Peptide-1 Receptors: Promising Therapeutic Targets for an Effective Management of Diabetes Mellitus. Current Pharmaceutical Design. DOI : 10.2174/1381612826666200131143231

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