TY - JOUR ID - 1138 TI - A lectin S-domain receptor kinase mediates lipopolysaccharide sensing in Arabidopsis thaliana JO - Nat. Immunol. PY - 2015 SP - 426-433 AU - Ranf, S. AU - Gisch, N. AU - Schäffer, M. AU - Illig, T. AU - Westphal, L. AU - Knirel, Y. A. AU - Sánchez-Carballo, P. M. AU - Zähringer, U. AU - Hückelhoven, R. AU - Lee, J. AU - Scheel, D. AU - VL - 16 UR - DO - 10.1038/ni.3124 AB - The sensing of microbe-associated molecular patterns (MAMPs) triggers innate immunity in animals and plants. Lipopolysaccharide (LPS) from Gram-negative bacteria is a potent MAMP for mammals, with the lipid A moiety activating proinflammatory responses via Toll-like receptor 4 (TLR4). Here we found that the plant Arabidopsis thaliana specifically sensed LPS of Pseudomonas and Xanthomonas. We isolated LPS-insensitive mutants defective in the bulb-type lectin S-domain-1 receptor–like kinase LORE (SD1-29), which were hypersusceptible to infection with Pseudomonas syringae. Targeted chemical degradation of LPS from Pseudomonas species suggested that LORE detected mainly the lipid A moiety of LPS. LORE conferred sensitivity to LPS onto tobacco after transient expression, which demonstrated a key function in LPS sensing and indicated the possibility of engineering resistance to bacteria in crop species. A2 - C1 - Biochemistry of Plant Interactions ER -