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Publikationen - Natur- und Wirkstoffchemie

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Publikation

Wessjohann, L.; Krass, N.; Yu, D.; de Meijere, A.; A New Versatile Synthesis of Ring-Substituted 2-Cyclopropylglycines and Related Amino Acids Chem. Ber. 125, 867-882, (1992) DOI: 10.1002/cber.19921250418

Alkyl 2‐chloro‐2‐cyclopropylideneacetates 2 serve as universal starting materials for a new general synthesis of cyclopro‐pylglycines by a simple three‐ to four‐step methodology. 1,4‐Addition of nucleophiles, substitution with azide ion, and mild catalytic deprotection lead to a variety of salt‐free cyclopropyl‐substituted amino acids in good yields, including the natural products 2‐(1‐methylcyclopropyl)glycine (4 ) and cleonin (5 ).
Publikation

Baumert, A.; Porzel, A.; Schmidt, J.; Gröger, D.; Formation of 1,3-Dihydroxy-N-methylacridone from N-Methylanthraniloyl-CoA and Malonyl-CoA by Cell-Free Extracts of Ruta graveolens Z. Naturforsch. C 47, 365-368, (1992) DOI: 10.1515/znc-1992-0608

N-Methylanthraniloyl-CoA was synthesized via N-succinimidyl N-methylanthranilate and subsequent transesterification with CoA-SH . This compound was characterized by LSIMS and NMR data. An enzyme preparation from cell suspension cultures of Ruta graveolens catalyzed the formation of 1,3-dihydroxy-N-methylacridone from N-methylanthraniloyl-CoA and malonyl-CoA with a pH optimum of 7.5.
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