Müllers, Y.; Sadr, A. S.; Schenderlein, M.; Pallab, N.; D. Davari, M.; Glebe, U.; Reifarth, M.; Acrylate‐derived RAFT polymers for enzyme hyperactivation – boosting the α‐chymotrypsin enzyme activity using tailor‐made poly(2‐carboxyethyl)acrylate (PCEA) ChemCatChem (2024) DOI: 10.1002/cctc.202301685

Struwe, H.; Droste, J.; Dhar, D.; Davari, M. D.; Kirschning, A.; Chemoenzymatic synthesis of a new germacrene derivative named germacrene F ChemBioChem 25, e202300599, (2024) DOI: 10.1002/cbic.202300599

Méndez, Y.; Vasco, A. V.; Ebensen, T.; Schulze, K.; Yousefi, M.; Davari, M. D.; Wessjohann, L. A.; Guzmán, C. A.; Rivera, D. G.; Westermann, B.; Diversification of a novel α‐galactosyl ceramide hotspot boosts the adjuvant properties in parenteral and mucosal vaccines Angew. Chem. Int. Ed. 63, e202310983, (2024) DOI: 10.1002/anie.202310983

Hashemi Haeri, H.; Schneegans, N.; Eisenschmidt-Bönn, D.; Brandt, W.; Wittstock, U.; Hinderberger, D.; Characterization of the active site in the thiocyanate-forming protein from Thlaspi arvense (TaTFP) using EPR spectroscopy Biol. Chem. 405, 105-118, (2024) DOI: 10.1515/hsz-2023-0187

Frey, M.; Bathe, U.; Meink, L.; Balcke, G. U.; Schmidt, J.; Frolov, A.; Soboleva, A.; Hassanin, A.; Davari, M. D.; Frank, O.; Schlagbauer, V.; Dawid, C.; Tissier, A.; Combinatorial biosynthesis in yeast leads to over 200 diterpenoids Metab. Eng. 82, 193-200, (2024) DOI: 10.1016/j.ymben.2024.02.006

Hemmer, S.; Siedhoff, N. E.; Werner, S.; Ölçücü, G.; Schwaneberg, U.; Jaeger, K.-E.; Davari, M. D.; Krauss, U.; Machine learning-assisted engineering of light, oxygen, voltage photoreceptor adduct lifetime JACS Au 3, 3311-3323, (2023) DOI: 10.1021/jacsau.3c00440

Hansen, C. C.; Sørensen, M.; Bellucci, M.; Brandt, W.; Olsen, C. E.; Goodger, J. Q. D.; Woodrow, I. E.; Lindberg Møller, B.; Neilson, E. H. J.; Recruitment of distinct UDP‐glycosyltransferase families demonstrates dynamic evolution of chemical defense within Eucalyptus L\'Hér New Phytol. 237, 999-1013, (2023) DOI: 10.1111/nph.18581

Abhishek, S.; Deeksha, W.; Nethravathi, K. R.; Davari, M. D.; Rajakumara, E.; Allosteric crosstalk in modular proteins: Function fine-tuning and drug design Comp Struct Biotechnol J 21, 5003-5015, (2023) DOI: 10.1016/j.csbj.2023.10.013

Nikolaiczyk, V.; Irwan, J.; Nguyen, T.; Fohrer, J.; Elbers, P.; Schrank, P.; Davari, M. D.; Kirschning, A.; Rational reprogramming of the sesquiterpene synthase BcBOT2 yields new terpenes with presilphiperfolane skeleton Catal. Sci. Technol. 13, 233-244, (2023) DOI: 10.1039/d2cy01617f

Meng, S.; Li, Z.; Ji, Y.; Ruff, A. J.; Liu, L.; Davari, M. D.; Schwaneberg, U.; Introduction of aromatic amino acids in electron transfer pathways yielded improved catalytic performance of cytochrome P450s Chin. J. Catal. 49, 81-90, (2023) DOI: 10.1016/s1872-2067(23)64445-6

Liu, Y.; Li, Z.; Cao, C.; Zhang, X.; Meng, S.; Davari, M. D.; Xu, H.; Ji, Y.; Schwaneberg, U.; Liu, L.; Engineering of substrate tunnel of P450 CYP116B3 though machine learning Catalysts 13, 1228, (2023) DOI: 10.3390/catal13081228

Lam, Y. T. H.; Hoppe, J.; Dang, Q. N.; Porzel, A.; Soboleva, A.; Brandt, W.; Rennert, R.; Hussain, H.; Davari, M. D.; Wessjohann, L.; Arnold, N.; Purpurascenines A–C, azepino-indole alkaloids from Cortinarius purpurascens: Isolation, biosynthesis, and activity studies on the 5-HT2A receptor J. Nat. Prod. 86, 1373-1384, (2023) DOI: 10.1021/acs.jnatprod.2c00716

Ihlenburg, R. B. J.; Petracek, D.; Schrank, P.; Davari, M. D.; Taubert, A.; Rothenstein, D.; Identification of the first sulfobetaine hydrogel‐binding peptides via phage display assay Macromolecular Rapid Communications 44, 2200896, (2023) DOI: 10.1002/marc.202200896

Rodríguez-Núñez, K.; Cortés-Monroy, A.; Serey, M.; Ensari, Y.; Davari, M. D.; Bernal, C.; Martinez, R.; Modulating substrate specificity of Rhizobium sp. Histamine Dehydrogenase through protein engineering for food quality applications Molecules 28, 3748, (2023) DOI: 10.3390/molecules28093748

Rajakumara, E.; Saniya, D.; Bajaj, P.; Rajeshwari, R.; Giri, J.; Davari, M. D.; Hijacking chemical reactions of P450 enzymes for altered chemical reactions and asymmetric synthesis Int. J. Mol. Sci. 24, 214, (2023) DOI: 10.3390/ijms24010214

Pourhassan, Z. N.; Cui, H.; Muckhoff, N.; Davari, M. D.; Smits, S. H. J.; Schwaneberg, U.; Schmitt, L.; A step forward to the optimized HlyA type 1 secretion system through directed evolution Applied Microbiology and Biotechnology 107, 5131-5143, (2023) DOI: 10.1007/s00253-023-12653-7

Pick, L. M.; Wenzlaff, J.; Yousefi, M.; Davari, M.; Ansorge-Schumacher, M.; Lipase‐mediated conversion of protecting group silyl ethers: An unspecific side reaction ChemBioChem 24, e202300384, (2023) DOI: 10.1002/cbic.202300384

Illig, A.-M.; Siedhoff, N. E.; Schwaneberg, U.; Davari, M. D.; A hybrid model combining evolutionary probability and machine learning leverages data-driven protein engineering bioRxiv (2022) DOI: 10.1101/2022.06.07.495081

Fu, N.; Becker, T.; Brandt, W.; Kunert, M.; Burse, A.; Boland, W.; Involvement of CYP347W1 in neurotoxin 3‐nitropropionic acid based chemical defense in mustard leaf beetle Phaedon cochleariae Insect Sci. 29, 453–466, (2022) DOI: 10.1111/1744-7917.12944

El Harrar, T.; Davari, M. D.; Jaeger, K.-E.; Schwaneberg, U.; Gohlke, H.; Critical assessment of structure-based approaches to improve protein resistance in aqueous ionic liquids by enzyme-wide saturation mutagenesis Comp Struct Biotechnol J 20, 399-409, (2022) DOI: 10.1016/j.csbj.2021.12.018

Dippe, M.; Davari, M. D.; Weigel, B.; Heinke, R.; Vogt, T.; Wessjohann, L. A.; Altering the regiospecificity of a catechol O‐methyltransferase through rational design: Vanilloid vs. isovanilloid motifs in the B‐ring of flavonoids ChemCatChem 14, e202200511, (2022) DOI: 10.1002/cctc.202200511

Cui, H.; Vedder, M.; Zhang, L.; Jaeger, K.-E.; Schwaneberg, U.; Davari, M. D.; Polar substitutions on the surface of a lipase substantially improve tolerance in organic solvents ChemSusChem 15, e202102551, (2022) DOI: 10.1002/cssc.202102551

Cui, H.; Zhang, L.; Yildiz, C. B.; Eltoukhy, L.; Cheng, L.; Jaeger, K.-E.; Schwaneberg, U.; Davari, M. D.; Enzyme hydration: How to retain resistance in ionic liquids ACS Sustainable Chemistry & Engineering 10, 15104-15114, (2022) DOI: 10.1021/acssuschemeng.2c04216

Bienstein, M.; Minond, D.; Schwaneberg, U.; Davari, M. D.; Yildiz, D.; In silico and experimental ADAM17 kinetic modeling as basis for future screening system for modulators Int. J. Mol. Sci. 23, 1368, (2022) DOI: 10.3390/ijms23031368

Wittmund, M.; Cadet, F.; Davari, M. D.; Learning epistasis and residue coevolution patterns: Current trends and future perspectives for advancing enzyme engineering ACS Catal. 12, 14243-14263, (2022) DOI: 10.1021/acscatal.2c01426

Weigel, B.; Ludwig, J.; Weber, R. A.; Ludwig, S.; Lennicke, C.; Schrank, P.; Davari, M. D.; Nagia, M.; Wessjohann, L. A.; Heterocyclic and alkyne terpenoids by terpene synthase‐mediated biotransformation of non‐natural prenyl diphosphates: Access to new fragrances and probes ChemBioChem 23, e202200211, (2022) DOI: 10.1002/cbic.202200211

Rajakumara, E.; Abhishek, S.; Nitin, K.; Saniya, D.; Bajaj, P.; Schwaneberg, U.; Davari, M. D.; Structure and cooperativity in substrate–enzyme interactions: Perspectives on enzyme engineering and inhibitor design ACS Chem. Biol. 17, 266-280, (2022) DOI: 10.1021/acschembio.1c00500

Pramanik, S.; Cui, H.; Dhoke, G. V.; Yildiz, C. B.; Vedder, M.; Jaeger, K.-E.; Schwaneberg, U.; Davari, M. D.; How does surface charge engineering of Bacillus subtilis lipase A improve ionic liquid resistance? Lessons learned from molecular dynamics simulations ACS Sustainable Chemistry & Engineering 10, 2689-2698, (2022) DOI: 10.1021/acssuschemeng.1c07332

Moura, P. H. B.; Brandt, W.; Porzel, A.; Martins, R. C. C.; Leal, I. C. R.; Wessjohann, L. A.; Structural elucidation of an atropisomeric entcassiflavan-(4β→8)-epicatechin isolated from Dalbergia monetaria L.f. based on NMR and ECD calculations in comparison to experimental data Molecules 27, 2512, (2022) DOI: 10.3390/molecules27082512

Meng, S.; Ji, Y.; Zhu, L.; Dhoke, G. V.; Davari, M. D.; Schwaneberg, U.; The molecular basis and enzyme engineering strategies for improvement of coupling efficiency in cytochrome P450s Biotechnol. Adv. 61, 108051, (2022) DOI: 10.1016/j.biotechadv.2022.108051

Meng, S.; Ji, Y.; Liu, L.; Davari, M. D.; Schwaneberg, U.; Modulating the coupling efficiency of P450 BM3 by controlling water diffusion through access tunnel engineering ChemSusChem 15, e202102434, (2022) DOI: 10.1002/cssc.202102434

Li, Z.; Meng, S.; Nie, K.; Schwaneberg, U.; Davari, M. D.; Xu, H.; Ji, Y.; Liu, L.; Flexibility regulation of loops surrounding the tunnel entrance in cytochrome P450 enhanced substrate access substantially ACS Catal. 12, 12800-12808, (2022) DOI: 10.1021/acscatal.2c02258

Körfer, G.; Besirlioglu, V.; Davari, M. D.; Martinez, R.; Vojcic, L.; Schwaneberg, U.; Combinatorial InVitroFlow‐assisted Mutagenesis (CombIMut) yields a 41‐fold improved CelA2 cellulase Biotechnology and Bioengineering 119, 2076–2087, (2022) DOI: 10.1002/bit.28110

Pourhassan N., Z.; Cui, H.; Khosa, S.; Davari, M. D.; Jaeger, K.; Smits, S. H. J.; Schwaneberg, U.; Schmitt, L.; Optimized hemolysin Type 1 secretion system in Escherichia coli by directed evolution of the Hly enhancer fragment and including a terminator region ChemBioChem 23, e202100702, (2022) DOI: 10.1002/cbic.202100702

Naumann, C.; Heisters, M.; Brandt, W.; Janitza, P.; Alfs, C.; Tang, N.; Toto Nienguesso, A.; Ziegler, J.; Imre, R.; Mechtler, K.; Dagdas, Y.; Hoehenwarter, W.; Sawers, G.; Quint, M.; Abel, S.; Bacterial-type ferroxidase tunes iron-dependent phosphate sensing during Arabidopsis root development Curr. Biol. 32, 2189-2205, (2022) DOI: 10.1016/j.cub.2022.04.005

Zabel, S.; Brandt, W.; Porzel, A.; Athmer, B.; Bennewitz, S.; Schäfer, P.; Kortbeek, R. W. J.; Bleeker, P. M.; Tissier, A.; A single cytochrome P450 oxidase from Solanum habrochaites sequentially oxidizes 7-epi-zingiberene to derivatives toxic to whiteflies and various microorganisms Plant J. 105, 1309-1325, (2021) DOI: 10.1111/tpj.15113

Sinelnikov, I. G.; Siedhoff, N. E.; Chulkin, A. M.; Zorov, I. N.; Schwaneberg, U.; Davari, M. D.; Sinitsyna, O. A.; Shcherbakova, L. A.; Sinitsyn, A. P.; Rozhkova, A. M.; Expression and refolding of the plant chitinase from Drosera capensis for applications as a sustainable and integrated pest management Front. Bioeng. Biotechnol. 9, 728501, (2021) DOI: 10.3389/fbioe.2021.728501

Lemfack, M. C.; Brandt, W.; Krüger, K.; Gurowietz, A.; Djifack, J.; Jung, J.-P.; Hopf, M.; Noack, H.; Junker, B.; von Reuß, S.; Piechulla, B.; Reaction mechanism of the farnesyl pyrophosphate C-methyltransferase towards the biosynthesis of pre-sodorifen pyrophosphate by Serratia plymuthica 4Rx13 Sci. Rep. 11, 3182, (2021) DOI: 10.1038/s41598-021-82521-9

Fricke, P. M.; Lürkens, M.; Hünnefeld, M.; Sonntag, C. K.; Bott, M.; Davari, M. D.; Polen, T.; Highly tunable TetR-dependent target gene expression in the acetic acid bacterium Gluconobacter oxydans Applied Microbiology and Biotechnology 105, 6835-6852, (2021) DOI: 10.1007/s00253-021-11473-x

Cheng, L.; Zhang, H.; Cui, H.; Davari, M. D.; Wei, B.; Wang, W.; Yuan, Q.; Efficient enzyme-catalyzed production of diosgenin: inspired by the biotransformation mechanisms of steroid saponins in Talaromyces stollii CLY-6 Green Chemistry 23, 5896-5910, (2021) DOI: 10.1039/d0gc04152a

Brandt, W.; Schulze, E.; Liberman-Aloni, R.; Bartelt, R.; Pienkny, S.; Carmeli-Weissberg, M.; Frydman, A.; Eyal, Y.; Structural modeling of two plant UDP-dependent sugar-sugar glycosyltransferases reveals a conserved glutamic acid residue that is a hallmark for sugar acceptor recognition Journal of Structural Biology 213, 107777, (2021) DOI: 10.1016/j.jsb.2021.107777

Zabel, S.; Brandt, W.; Porzel, A.; Athmer, B.; Kortbeek, R. W. J.; Bleeker, P. M.; Tissier, A.; Two novel 7-epi-zingiberene derivatives with biological activity from Solanum habrochaites are produced by a single cytochrome P450 monooxygenase bioRxiv (2020) DOI: 10.1101/2020.04.21.052571

Böhme, B.; Moritz, B.; Wendler, J.; Hertel, T. C.; Ihling, C.; Brandt, W.; Pietzsch, M.; Enzymatic activity and thermoresistance of improved microbial transglutaminase variants Amino Acids 52, 313-326, (2020) DOI: 10.1007/s00726-019-02764-9

Jouda, J.-B.; Njoya, E. M.; Fobofou, S. A. T.; Zhou, Z. Y.; Qiang, Z.; Mbazoa, C. D.; Brandt, W.; Zhang, G.-l.; Wandji, J.; Wang, F.; Natural Polyketides Isolated from the Endophytic Fungus Phomopsis sp. CAM212 with a Semisynthetic Derivative Downregulating the ERK/IκBα Signaling Pathways Planta Med. 86, 1032-1042, (2020) DOI: 10.1055/a-1212-2930

Holzmeyer, L.; Hartig, A.-K.; Franke, K.; Brandt, W.; Muellner-Riehl, A. N.; Wessjohann, L. A.; Schnitzler, J.; Evaluation of plant sources for antiinfective lead compound discovery by correlating phylogenetic, spatial, and bioactivity data Proc. Natl. Acad. Sci. U.S.A. 117, 12444-12451, (2020) DOI: 10.1073/pnas.1915277117

Fellenberg, C.; Corea, O.; Yan, L.; Archinuk, F.; Piirtola, E.; Gordon, H.; Reichelt, M.; Brandt, W.; Wulff, J.; Ehlting, J.; Constabel, C. P.; Discovery of salicyl benzoate UDP‐glycosyltransferase, a central enzyme in poplar salicinoid phenolic glycoside biosynthesis Plant J. 102, 99-115, (2020) DOI: 10.1111/tpj.14615

Vasco, A. V.; Moya, C. G.; Gröger, S.; Brandt, W.; Balbach, J.; Pérez, C. S.; Wessjohann, L. A.; Rivera, D. G.; Insights into the secondary structures of lactam N-substituted stapled peptides Org. Biomol. Chem. 18, 3838-3842, (2020) DOI: 10.1039/D0OB00767F

Sheludko, Y. V.; Volk, J.; Brandt, W.; Warzecha, H.; Expanding the diversity of plant monoterpenoid indole alkaloids employing human cytochrome P450 3A4 ChemBioChem 21, 1976-1980, (2020) DOI: 10.1002/cbic.202000020

Schnabel, A.; Cotinguiba, F.; Athmer, B.; Yang, C.; Westermann, B.; Schaks, A.; Porzel, A.; Brandt, W.; Schumacher, F.; Vogt, T.; A piperic acid CoA ligase produces a putative precursor of piperine, the pungent principle from black pepper fruits Plant J. 102, 569-581, (2020) DOI: 10.1111/tpj.14652

Neubauer, P. R.; Pienkny, S.; Wessjohann, L. A.; Wessjohann, L.; Brandt, W.; Sewald, N.; Predicting the substrate scope of the flavin‐dependent halogenase BrvH ChemBioChem 21, 3282–3288, (2020) DOI: 10.1002/cbic.202000444

Francioso, A.; Franke, K.; Villani, C.; Mosca, L.; d’Erme, M.; Frischbutter, S.; Brandt, W.; Sanchez-Lamar, A.; Wessjohann, L.; Insights into the Phytochemistry of the Cuban Endemic Medicinal Plant Phyllanthus orbicularis: Fideloside, a Novel Bioactive 8-C-glycosyl 2,3-Dihydroflavonol (Pinarosa Avato). Molecules 79-92, (2020) ISBN: 978-3-03928-746-8 DOI: 10.3390/books978-3-03928-747-5

Fu, N.; Yang, Z.-l.; Pauchet, Y.; Paetz, C.; Brandt, W.; Boland, W.; Burse, A.; A cytochrome P450 from juvenile mustard leaf beetles hydroxylates geraniol, a key step in iridoid biosynthesis bioRxiv (2019) DOI: 10.1101/634485

Loesche, A.; Kahnt, M.; Serbian, I.; Brandt, W.; Csuk, R.; Triterpene-Based Carboxamides Act as Good Inhibitors of Butyrylcholinesterase Molecules 24, 948, (2019) DOI: 10.3390/molecules24050948

Loesche, A.; Wiemann, J.; Rohmer, M.; Brandt, W.; Csuk, R.; Novel 12-hydroxydehydroabietylamine derivatives act as potent and selective butyrylcholinesterase inhibitors Bioorg. Chem. 90, 103092, (2019) DOI: 10.1016/j.bioorg.2019.103092

Eisermann, I.; Weihmann, F.; Krijger, J.; Kröling, C.; Hause, G.; Menzel, M.; Pienkny, S.; Kiesow, A.; Deising, H. B.; Wirsel, S. G. R.; Two genes in a pathogenicity gene cluster encoding secreted proteins are required for appressorial penetration and infection of the maize anthracnose fungus Colletotrichum graminicola Environ. Microbiol. 21, 4773-4791, (2019) DOI: 10.1111/1462-2920.14819

Eisenschmidt-Bönn, D.; Schneegans, N.; Backenköhler, A.; Wittstock, U.; Brandt, W.; Structural diversification during glucosinolate breakdown: mechanisms of thiocyanate, epithionitrile and simple nitrile formation Plant J. 99, 329-343, (2019) DOI: 10.1111/tpj.14327

Fu, N.; Yang, Z.-l.; Pauchet, Y.; Paetz, C.; Brandt, W.; Boland, W.; Burse, A.; A cytochrome P450 from the mustard leaf beetles hydroxylates geraniol, a key step in iridoid biosynthesis Insect Biochem. Mol. Biol. 113, 103212, (2019) DOI: 10.1016/j.ibmb.2019.103212

Francioso, A.; Franke, K.; Villani, C.; Mosca, L.; d’Erme, M.; Frischbutter, S.; Brandt, W.; Sanchez-Lamar, A.; Wessjohann, L.; Insights into the Phytochemistry of the Cuban Endemic Medicinal Plant Phyllanthus orbicularis: Fideloside, a Novel Bioactive 8-C-glycosyl 2,3-Dihydroflavonol Molecules 24, 2855, (2019) DOI: 10.3390/molecules24152855

Wang, D.; Pentzold, S.; Kunert, M.; Groth, M.; Brandt, W.; Pasteels, J. M.; Boland, W.; Burse, A.; A subset of chemosensory genes differs between two populations of a specialized leaf beetle after host plant shift Ecol. Evol. 8, 8055-8075, (2018) DOI: 10.1002/ece3.4246

Vattekkatte, A.; Garms, S.; Brandt, W.; Boland, W.; Enhanced structural diversity in terpenoid biosynthesis: enzymes, substrates and cofactors Org. Biomol. Chem. 16, 348-362, (2018) DOI: 10.1039/C7OB02040F

Schüler, J.-A.; Neumann, S.; Müller-Hannemann, M.; Brandt, W.; ChemFrag: Chemically meaningful annotation of fragment ion mass spectra J. Mass Spectrom. 53, 1104-1115, (2018) DOI: 10.1002/jms.4278

Lohmann, J. S.; von Nussbaum, M.; Brandt, W.; Mülbradt, J.; Steglich, W.; Spiteller, P.; Rosellin A and B, two red diketopiperazine alkaloids from the mushroom Mycena rosella Tetrahedron 74, 5113-5118, (2018) DOI: 10.1016/j.tet.2018.06.049

Backenköhler, A.; Eisenschmidt, D.; Schneegans, N.; Strieker, M.; Brandt, W.; Wittstock, U.; Iron is a centrally bound cofactor of specifier proteins involved in glucosinolate breakdown PLOS ONE 13, e0205755, (2018) DOI: 10.1371/journal.pone.0205755

Fechner, J.; Kaufmann, M.; Herz, C.; Eisenschmidt, D.; Lamy, E.; Kroh, L. W.; Hanschen, F. S.; The major glucosinolate hydrolysis product in rocket (Eruca sativa L.), sativin, is 1,3-thiazepane-2-thione: Elucidation of structure, bioactivity, and stability compared to other rocket isothiocyanates Food Chem. 261, 57-65, (2018) DOI: 10.1016/j.foodchem.2018.04.023

Otto, A.; Porzel, A.; Westermann, B.; Brandt, W.; Wessjohann, L.; Arnold, N.; Structural and stereochemical elucidation of new hygrophorones from Hygrophorus abieticola (Basidiomycetes) Tetrahedron 73, 1682-1690, (2017) DOI: 10.1016/j.tet.2017.02.013

Natalio, F.; Wiese, S.; Brandt, W.; Wessjohann, L.; Reconstitution of Vanadium Haloperoxidase's Catalytic Activity by Boric Acid-Towards a Potential Biocatalytic Role of Boron Chem.-Eur. J. 23, 4973-4980, (2017) DOI: 10.1002/chem.201605230

Loesche, A.; Wiese, J.; Sommerwerk, S.; Simon, V.; Brandt, W.; Csuk, R.; Repurposing N,N'-bis-(arylamidino)-1,4-piperazinedicarboxamidines: An unexpected class of potent inhibitors of cholinesterases Eur. J. Med. Chem. 125, 430-434, (2017) DOI: 10.1016/j.ejmech.2016.09.051

Heller, L.; Kahnt, M.; Loesche, A.; Grabandt, P.; Schwarz, S.; Brandt, W.; Csuk, R.; Amino derivatives of platanic acid act as selective and potent inhibitors of butyrylcholinesterase Eur. J. Med. Chem. 126, 652-668, (2017) DOI: 10.1016/j.ejmech.2016.11.056

Rissel, D.; Heym, P. P.; Thor, K.; Brandt, W.; Wessjohann, L. A.; Peiter, E.; No Silver Bullet – Canonical Poly(ADP-Ribose) Polymerases (PARPs) Are No Universal Factors of Abiotic and Biotic Stress Resistance of Arabidopsis thaliana Front. Plant Sci. 8, 59, (2017) DOI: 10.3389/fpls.2017.00059

Wiemann, J.; Karasch, J.; Loesche, A.; Heller, L.; Brandt, W.; Csuk, R.; Piperlongumine B and analogs are promising and selective inhibitors for acetylcholinesterase Eur. J. Med. Chem. 139, 222-231, (2017) DOI: 10.1016/j.ejmech.2017.07.081

Cotrim, C. A.; Weidner, A.; Strehmel, N.; Bisol, T. B.; Meyer, D.; Brandt, W.; Wessjohann, L. A.; Stubbs, M. T.; A Distinct Aromatic Prenyltransferase Associated with the Futalosine Pathway ChemistrySelect 2, 9319-9325, (2017) DOI: 10.1002/slct.201702151

Bilova, T.; Paudel, G.; Shilyaev, N.; Schmidt, R.; Brauch, D.; Tarakhovskaya, E.; Milrud, S.; Smolikova, G.; Tissier, A.; Vogt, T.; Sinz, A.; Brandt, W.; Birkemeyer, C.; Wessjohann, L. A.; Frolov, A.; Global proteomic analysis of advanced glycation end products in the Arabidopsis proteome provides evidence for age-related glycation hot spots J. Biol. Chem. 292, 15758-15776, (2017) DOI: 10.1074/jbc.M117.794537

Wessjohann, L. A.; Bartelt, R.; Brandt, W.; Natural and Nature-Inspired Macrocycles: A Chemoinformatic Overview and Relevant Examples (Marsault, E. & Peterson, M. L., eds.). 77-100, (2017) ISBN: 978-1-11909-259-9 DOI: 10.1002/9781119092599.ch4

Kaluđerović, G. N.; Hernández-Corroto, E.; Brandt, W.; Zmejkovski, B. B.; Gómez-Ruiz, S.; Palladium(II) complexes with R2edda-derived ligands J. Coord. Chem. 69, 1337-1345, (2016) DOI: 10.1080/00958972.2016.1168519

Fobofou, S. A. T.; Franke, K.; Porzel, A.; Brandt, W.; Wessjohann, L. A.; Tricyclic Acylphloroglucinols from Hypericum lanceolatum and Regioselective Synthesis of Selancins A and B J. Nat. Prod. 79, 743-753, (2016) DOI: 10.1021/acs.jnatprod.5b00673

Scheler, U.; Brandt, W.; Porzel, A.; Rothe, K.; Manzano, D.; Božić, D.; Papaefthimiou, D.; Balcke, G. U.; Henning, A.; Lohse, S.; Marillonnet, S.; Kanellis, A. K.; Ferrer, A.; Tissier, A.; Elucidation of the biosynthesis of carnosic acid and its reconstitution in yeast Nat. Commun. 7, 12942, (2016) DOI: 10.1038/ncomms12942

Piechulla, B.; Bartelt, R.; Brosemann, A.; Effmert, U.; Bouwmeester, H.; Hippauf, F.; Brandt, W.; The α-Terpineol to 1,8-Cineole Cyclization Reaction of Tobacco Terpene Synthases Plant Physiol. 172, 2120-2131, (2016) DOI: 10.1104/pp.16.01378

Paudel, G.; Bilova, T.; Schmidt, R.; Greifenhagen, U.; Berger, R.; Tarakhovskaya, E.; Stöckhardt, S.; Balcke, G. U.; Humbeck, K.; Brandt, W.; Sinz, A.; Vogt, T.; Birkemeyer, C.; Wessjohann, L.; Frolov, A.; Osmotic stress is accompanied by protein glycation in Arabidopsis thaliana J. Exp. Bot. 67, 6283-6295, (2016) DOI: 10.1093/jxb/erw395

Otto, A.; Porzel, A.; Schmidt, J.; Brandt, W.; Wessjohann, L.; Arnold, N.; Structure and Absolute Configuration of Pseudohygrophorones A12 and B12, Alkyl Cyclohexenone Derivatives from Hygrophorus abieticola (Basidiomycetes) J. Nat. Prod. 79, 74-80, (2016) DOI: 10.1021/acs.jnatprod.5b00675

Otto, M.; Naumann, C.; Brandt, W.; Wasternack, C.; Hause, B.; Activity Regulation by Heteromerization of Arabidopsis Allene Oxide Cyclase Family Members Plants 5, 3, (2016) DOI: 10.3390/plants5010003

Dieckow, J.; Brandt, W.; Hattermann, K.; Schob, S.; Schulze, U.; Mentlein, R.; Ackermann, P.; Sel, S.; Paulsen, F. P.; CXCR4 and CXCR7 Mediate TFF3-Induced Cell Migration Independently From the ERK1/2 Signaling Pathway Invest. Ophthalmol. Vis. Sci. 57, 56-65, (2016) DOI: 10.1167/iovs.15-18129

Weigl, S.; Brandt, W.; Langhammer, R.; Roos, W.; The Vacuolar Proton-Cation Exchanger EcNHX1 Generates pH Signals for the Expression of Secondary Metabolism in Eschscholzia californica Plant Physiol. 170, 1135-1148, (2016) DOI: 10.1104/pp.15.01570

Faden, F.; Ramezani, T.; Mielke, S.; Almudi, I.; Nairz, K.; Froehlich, M. S.; Höckendorff, J.; Brandt, W.; Hoehenwarter, W.; Dohmen, R. J.; Schnittger, A.; Dissmeyer, N.; Phenotypes on demand via switchable target protein degradation in multicellular organisms Nat. Commun. 7, 12202, (2016) DOI: 10.1038/ncomms12202

Domik, D.; Thürmer, A.; Weise, T.; Brandt, W.; Daniel, R.; Piechulla, B.; A Terpene Synthase Is Involved in the Synthesis of the Volatile Organic Compound Sodorifen of Serratia plymuthica 4Rx13 Front. Microbiol. 7, 737, (2016) DOI: 10.3389/fmicb.2016.00737

Brandt, W.; Manke, K.; Vogt, T.; A catalytic triad – Lys-Asn-Asp – Is essential for the catalysis of the methyl transfer in plant cation-dependent O-methyltransferases Phytochemistry 113, 130-139, (2015) DOI: 10.1016/j.phytochem.2014.12.018

Bobach, C.; Tennstedt, S.; Palberg, K.; Denkert, A.; Brandt, W.; de Meijere, A.; Seliger, B.; Wessjohann, L. A.; Screening of synthetic and natural product databases: Identification of novel androgens and antiandrogens Eur. J. Med. Chem. 90, 267-279, (2015) DOI: 10.1016/j.ejmech.2014.11.026

Rahfeld, P.; Haeger, W.; Kirsch, R.; Pauls, G.; Becker, T.; Schulze, E.; Wielsch, N.; Wang, D.; Groth, M.; Brandt, W.; Boland, W.; Burse, A.; Glandular β-glucosidases in juvenile Chrysomelina leaf beetles support the evolution of a host-plant-dependent chemical defense Insect Biochem. Mol. Biol. 58, 28-38, (2015) DOI: 10.1016/j.ibmb.2015.01.003

Yahyaa, M.; Matsuba, Y.; Brandt, W.; Doron-Faigenboim, A.; Bar, E.; McClain, A.; Davidovich-Rikanati, R.; Lewinsohn, E.; Pichersky, E.; Ibdah, M.; Identification, Functional Characterization, and Evolution of Terpene Synthases from a Basal Dicot Plant Physiol. 169, 1683-1697, (2015) DOI: 10.1104/pp.15.00930

Vattekkatte, A.; Gatto, N.; Schulze, E.; Brandt, W.; Boland, W.; Inhibition of a multiproduct terpene synthase from Medicago truncatula by 3-bromoprenyl diphosphates Org. Biomol. Chem. 13, 4776-4784, (2015) DOI: 10.1039/c5ob00506j

Khalil, M. N.; Brandt, W.; Beuerle, T.; Reckwell, D.; Groeneveld, J.; Hänsch, R.; Gaid, M. M.; Liu, B.; Beerhues, L.; O-Methyltransferases involved in biphenyl and dibenzofuran biosynthesis Plant J. 83, 263-276, (2015) DOI: 10.1111/tpj.12885

Heinze, M.; Brandt, W.; Marillonnet, S.; Roos, W.; “Self” and “Non-Self” in the Control of Phytoalexin Biosynthesis: Plant Phospholipases A2 with Alkaloid-Specific Molecular Fingerprints Plant Cell 27, 448-462, (2015) DOI: 10.1105/tpc.114.135343

Gumz, F.; Krausze, J.; Eisenschmidt, D.; Backenköhler, A.; Barleben, L.; Brandt, W.; Wittstock, U.; The crystal structure of the thiocyanate-forming protein from Thlaspi arvense, a kelch protein involved in glucosinolate breakdown Plant Mol. Biol. 89, 67-81, (2015) DOI: 10.1007/s11103-015-0351-9

Farag, M. A.; Al-Mahdy, D. A.; Salah El Dine, R.; Fahmy, S.; Yassin, A.; Porzel, A.; Brandt, W.; Structure-Activity Relationships of Antimicrobial Gallic Acid Derivatives from Pomegranate and Acacia Fruit Extracts against Potato Bacterial Wilt Pathogen Chem. Biodivers. 12, 955-962, (2015) DOI: 10.1002/cbdv.201400194

Dippe, M.; Brandt, W.; Rost, H.; Porzel, A.; Schmidt, J.; Wessjohann, L. A.; Rationally engineered variants of S-adenosylmethionine (SAM) synthase: reduced product inhibition and synthesis of artificial cofactor homologues Chem. Commun. 51, 3637-3640, (2015) DOI: 10.1039/c4cc08478k

Schicht, M.; Rausch, F.; Finotto, S.; Mathews, M.; Mattil, A.; Schubert, M.; Koch, B.; Traxdorf, M.; Bohr, C.; Worlitzsch, D.; Brandt, W.; Garreis, F.; Sel, S.; Paulsen, F.; Bräuer, L.; SFTA3, a novel protein of the lung: three-dimensional structure, characterisation and immune activation Eur. Respir. J. 44, 447-456, (2014) DOI: 10.1183/09031936.00179813

Reinhardt, N.; Fischer, J.; Coppi, R.; Blum, E.; Brandt, W.; Dräger, B.; Substrate flexibility and reaction specificity of tropinone reductase-like short-chain dehydrogenases Bioorg. Chem. 53, 37-49, (2014) DOI: 10.1016/j.bioorg.2014.01.004

Rausch, F.; Schicht, M.; Bräuer, L.; Paulsen, F.; Brandt, W.; Protein modeling and molecular dynamics simulation of the two novel surfactant proteins SP-G and SP-H J. Mol. Model. 20, 2513, (2014) DOI: 10.1007/s00894-014-2513-0

Nakamura, Y.; Paetz, C.; Brandt, W.; David, A.; Rendón-Anaya, M.; Herrera-Estrella, A.; Mithöfer, A.; Boland, W.; Synthesis of 6-Substituted 1-oxoindanoyl Isoleucine Conjugates and Modeling Studies with the COI1-JAZ Co-Receptor Complex of Lima Bean J. Chem. Ecol. 40, 687-699, (2014) DOI: 10.1007/s10886-014-0469-2

Mansfeld, J.; Schöpfel, M.; Lorenz, J.; Trutschel, T.; Heilmann, I.; Brandt, W.; Ulbrich-Hofmann, R.; Probing selected structural regions in the secreted phospholipase A2 from Arabidopsis thaliana for their impact on stability and activity Biochimie 101, 60-66, (2014) DOI: 10.1016/j.biochi.2013.12.015

Brandt, W.; Backenköhler, A.; Schulze, E.; Plock, A.; Herberg, T.; Roese, E.; Wittstock, U.; Molecular models and mutational analyses of plant specifier proteins suggest active site residues and reaction mechanism Plant Mol. Biol. 84, 173-188, (2014) DOI: 10.1007/s11103-013-0126-0

Bojahr, J.; Obst, K.; Brockhoff, A.; Reichelt, K.; Brandt, W.; Pienkny, S.; Ley, J. P.; Wessjohann, L.; Meyerhof, W.; Interaction of novel sweeteners from Mycetia balansae with the human sweet taste receptor (Hofmann, T., et al., eds.). 253-257, (2014)

Backes, M.; Vössing, T.; Aust, S.; Pienkny, S.; Brandt, W.; Wessjohann, L.; Ley, J. P.; Identification of nitrogen-containing flavonoids as a potent bitter masker supported by combined gustophore modeling and docking studies (Hofmann, T., et al., eds.). 29-34, (2014)

Rausch, F.; Brandt, W.; Schicht, M.; Bräuer, L.; Paulsen, F.; Protein modeling and molecular dynamic studies of two new surfactant proteins J. Cheminform. 5, O2, (2013) DOI: 10.1186/1758-2946-5-S1-O2

Nickerson, M. L.; Bosley, A. D.; Weiss, J. S.; Kostiha, B. N.; Hirota, Y.; Brandt, W.; Esposito, D.; Kinoshita, S.; Wessjohann, L.; Morham, S. G.; Andresson, T.; Kruth, H. S.; Okano, T.; Dean, M.; The UBIAD1 Prenyltransferase Links Menaquinone-4 Synthesis to Cholesterol Metabolic Enzymes Hum. Mutat. 34, 317-329, (2013) DOI: 10.1002/humu.22230

Kopycki, J.; Wieduwild, E.; Kohlschmidt, J.; Brandt, W.; Stepanova, A.; Alonso, J.; Pedras, M. S.; Abel, S.; Grubb, C. D.; Kinetic analysis of Arabidopsis glucosyltransferase UGT74B1 illustrates a general mechanism by which enzymes can escape product inhibition Biochem. J. 450, 37-46, (2013) DOI: 10.1042/BJ20121403

Junker, A.; Fischer, J.; Sichhart, Y.; Brandt, W.; Dräger, B.; Evolution of the key alkaloid enzyme putrescine N-methyltransferase from spermidine synthase Front. Plant Sci. 4, 260, (2013) DOI: 10.3389/fpls.2013.00260

Jocković, N.; Fischer, W.; Brandsch, M.; Brandt, W.; Dräger, B.; Inhibition of Human Intestinal α-Glucosidases by Calystegines J. Agr. Food Chem. 61, 5550-5557, (2013) DOI: 10.1021/jf4010737

Frick, S.; Nagel, R.; Schmidt, A.; Bodemann, R. R.; Rahfeld, P.; Pauls, G.; Brandt, W.; Gershenzon, J.; Boland, W.; Burse, A.; Metal ions control product specificity of isoprenyl diphosphate synthases in the insect terpenoid pathway Proc. Natl. Acad. Sci. U.S.A. 110, 4194-4199, (2013) DOI: 10.1073/pnas.1221489110

Wils, C. R.; Brandt, W.; Manke, K.; Vogt, T.; A single amino acid determines position specificity of an Arabidopsis thaliana CCoAOMT-like O-methyltransferase FEBS Lett. 587, 683-689, (2013) DOI: 10.1016/j.febslet.2013.01.040

Wessjohann, L. A.; Schneider, A.; Kaluđerović, G. N.; Brandt, W.; Solid-phase synthesis of reduced selenocysteine tetrapeptides and their oxidized analogs containing selenenylsulfide eight-membered rings Mol. Divers. 17, 537-545, (2013) DOI: 10.1007/s11030-013-9454-x

Stehle, F.; Götsch, F.; Wray, V.; Schmidt, J.; Strack, D.; Brandt, W.; Snap-shot of Serine Carboxypeptidase-like Acyltransferase Evolution: The Loss of Conserved Disulphide Bridge is Responsible for the Completion of Neo-functionalization J. Phylogenet. Evol. Biol. 1, 115, (2013) DOI: 10.4172/2329-9002.1000115

Solé, M.; Brandt, W.; Arnold, U.; Striking stabilization of Rana catesbeiana ribonuclease 3 by guanidine hydrochloride FEBS Lett. 587, 737-742, (2013) DOI: 10.1016/j.febslet.2013.01.056

Tennstedt, S.; Fischer, J.; Brandt, W.; Wessjohann, L.; Virtual screening - tools for a faster selection of new drug leads (Jelić, D., ed.). 219-236, (2013)

Rausch, F.; Schicht, M.; Paulsen, F.; Ngueya, I.; Bräuer, L.; Brandt, W.; “SP-G”, a Putative New Surfactant Protein – Tissue Localization and 3D Structure PLOS ONE 7, e47789, (2012) DOI: 10.1371/journal.pone.0047789

Rausch, F.; Molekülsimulation von Surfactant-Proteinen Ophthalmologische Nachrichten 12.2012, 13, (2012)

Ley, J. P.; Dessoy, M.; Paetz, S.; Blings, M.; Hoffmann-Lücke, P.; Reichelt, K. V.; Krammer, G. E.; Pienkny, S.; Brandt, W.; Wessjohann, L.; Identification of Enterodiol as a Masker for Caffeine Bitterness by Using a Pharmacophore Model Based on Structural Analogues of Homoeriodictyol J. Agr. Food Chem. 60, 6303-6311, (2012) DOI: 10.1021/jf301335z

Jimenez-Aleman, G. H.; Schöner, T.; Montero-Alejo, A. L.; Brandt, W.; Boland, W.; Improved synthesis of the chrysomelid pheromone (6R,7S)-(+)-himachala-9,11-diene via spontaneous bromination and didehydrobromination of 2,6,6,9-tetramethyl-bicyclo[5.4.0]undec-8-ene ARKIVOC 2012, 371-378, (2012) DOI: 10.3998/ark.5550190.0013.326

Heym, P.-P.; Brandt, W.; Wessjohann, L. A.; Niclas, H.-J.; Virtual screening for plant PARP inhibitors – what can be learned from human PARP inhibitors? J. Cheminform. 4, O24, (2012) DOI: 10.1186/1758-2946-4-S1-O24

Calderón Villalobos, L. I. A.; Lee, S.; De Oliveira, C.; Ivetac, A.; Brandt, W.; Armitage, L.; Sheard, L. B.; Tan, X.; Parry, G.; Mao, H.; Zheng, N.; Napier, R.; Kepinski, S.; Estelle, M.; A combinatorial TIR1/AFB–Aux/IAA co-receptor system for differential sensing of auxin Nat. Chem. Biol. 8, 477-485, (2012) DOI: 10.1038/nchembio.926

Amado, E.; Schöps, R.; Brandt, W.; Kressler, J.; Spontaneous Formation of Giant Bioactive Protein-Block Copolymer Vesicles in Water ACS Macro Lett. 1, 1016-1019, (2012) DOI: 10.1021/mz300304u

Walter, M. H.; Floss, D. S.; Paetzold, H.; Manke, K.; Vollrath, J.; Brandt, W.; Strack, D.; Control of Plastidial Isoprenoid Precursor Supply: Divergent 1-Deoxy-D-Xylulose 5-Phosphate Synthase (DXS) Isogenes Regulate the Allocation to Primary or Secondary Metabolism (Bach, T. J. & Rohmer, M., eds.). 251-270, (2012) ISBN: 978-1-4614-4063-5 DOI: 10.1007/978-1-4614-4063-5_17

Dąbrowska, P.; Shabab, M.; Brandt, W.; Vogel, H.; Boland, W.; Isomerization of the Phytohormone Precursor 12-Oxophytodienoic Acid (OPDA) in the Insect Gut J. Biol. Chem. 286, 22348-22354, (2011) DOI: 10.1074/jbc.M111.244509

Brandt, W.; Herberg, T.; Wessjohann, L.; Systematic conformational investigations of peptoids and peptoid-peptide chimeras Biopolymers 96, 651-668, (2011) DOI: 10.1002/bip.21620

Schneider, T.; Ba, L. A.; Khairan, K.; Zwergel, C.; Bach, N. D.; Bernhardt, I.; Brandt, W.; Wessjohann, L.; Diederich, M.; Jacob, C.; Interactions of polysulfanes with components of red blood cells Med. Chem. Commun. 2, 196-200, (2011) DOI: 10.1039/C0MD00203H

Nawaz, S. A.; Ayaz, M.; Brandt, W.; Wessjohann, L. A.; Westermann, B.; Cation–π and π–π stacking interactions allow selective inhibition of butyrylcholinesterase by modified quinine and cinchonidine alkaloids Biochem. Biophys. Res. Commun. 404, 935-940, (2011) DOI: 10.1016/j.bbrc.2010.12.084

Mansfeld, J.; Brandt, W.; Haftendorn, R.; Schöps, R.; Ulbrich-Hofmann, R.; Discrimination between the regioisomeric 1,2- and 1,3-diacylglycerophosphocholines by phospholipases Chem. Phys. Lipids 164, 196-204, (2011) DOI: 10.1016/j.chemphyslip.2010.12.009

Fredericks, W. J.; McGarvey, T.; Wang, H.; Lal, P.; Puthiyaveettil, R.; Tomaszewski, J.; Sepulveda, J.; Labelle, E.; Weiss, J. S.; Nickerson, M. L.; Kruth, H. S.; Brandt, W.; Wessjohann, L. A.; Malkowicz, S. B.; The Bladder Tumor Suppressor Protein TERE1 (UBIAD1) Modulates Cell Cholesterol: Implications for Tumor Progression DNA Cell Biol. 30, 851-864, (2011) DOI: 10.1089/dna.2011.1315

Nickerson, M. L.; Kostiha, B. N.; Brandt, W.; Fredericks, W.; Xu, K.-P.; Yu, F.-S.; Gold, B.; Chodosh, J.; Goldberg, M.; Lu, D. W.; Yamada, M.; Tervo, T. M.; Grutzmacher, R.; Croasdale, C.; Hoeltzenbein, M.; Sutphin, J.; Malkowicz, S. B.; Wessjohann, L.; Kruth, H. S.; Dean, M.; Weiss, J. S.; UBIAD1 Mutation Alters a Mitochondrial Prenyltransferase to Cause Schnyder Corneal Dystrophy PLOS ONE 5, e10760, (2010) DOI: 10.1371/journal.pone.0010760

Geissler, T.; Brandt, W.; Porzel, A.; Schlenzig, D.; Kehlen, A.; Wessjohann, L.; Arnold, N.; Acetylcholinesterase inhibitors from the toadstool Cortinarius infractus Bioorg. Med. Chem. 18, 2173-2177, (2010) DOI: 10.1016/j.bmc.2010.01.074

Busch, C.; Jacob, C.; Anwar, A.; Burkholz, T.; Ba, L. A.; Cerella, C.; Diederich, M.; Brandt, W.; Wessjohann, L.; Montenarh, M.; Diallylpolysulfides induce growth arrest and apoptosis Int. J. Oncol. 36, 743-749, (2010) DOI: 10.3892/ijo_00000550

Brandt, W.; Kufka, J.; Schulze, D.; Schulze, E.; Rausch, F.; Wessjohann, L.; The membrane bound aromatic p-hydroxybenzoic acid oligoprenyltransferase (UbiA) - how iterative improvements lead to a realistic structure that offers new insights into functional aspects of prenyl transferases and terpene synthases J. Cheminform. 2, O20, (2010) DOI: 10.1186/1758-2946-2-S1-O20

Brandt, W.; Haupt, V. J.; Wessjohann, L. A.; Chemoinformatic Analysis of Biologically Active Macrocycles Curr. Top. Med. Chem. 10, 1361-1379, (2010) DOI: 10.2174/156802610792232060

Ziegler, J.; Brandt, W.; Geißler, R.; Facchini, P. J.; Removal of Substrate Inhibition and Increase in Maximal Velocity in the Short Chain Dehydrogenase/Reductase Salutaridine Reductase Involved in Morphine Biosynthesis J. Biol. Chem. 284, 26758-26767, (2009) DOI: 10.1074/jbc.M109.030957

Ziegler, J.; Facchini, P. J.; Geißler, R.; Schmidt, J.; Ammer, C.; Kramell, R.; Voigtländer, S.; Gesell, A.; Pienkny, S.; Brandt, W.; Evolution of morphine biosynthesis in opium poppy Phytochemistry 70, 1696-1707, (2009) DOI: 10.1016/j.phytochem.2009.07.006

Wessjohann, L.; Zakharova, S.; Schulze, D.; Kufka, J.; Weber, R.; Bräuer, L.; Brandt, W.; Enzymatic C–C-Coupling Prenylation: Bioinformatics – Modelling – Mechanism – Protein-Redesign – Biocatalytic Application Chimia 63, 340-344, (2009) DOI: 10.2533/chimia.2009.340

Stehle, F.; Brandt, W.; Stubbs, M. T.; Milkowski, C.; Strack, D.; Sinapoyltransferases in the light of molecular evolution Phytochemistry 70, 1652-1662, (2009) DOI: 10.1016/j.phytochem.2009.07.023

Pienkny, S.; Brandt, W.; Schmidt, J.; Kramell, R.; Ziegler, J.; Functional characterization of a novel benzylisoquinoline O-methyltransferase suggests its involvement in papaverine biosynthesis in opium poppy (Papaver somniferum L) Plant J. 60, 56-67, (2009) DOI: 10.1111/j.1365-313X.2009.03937.x

Buchholz, M.; Brandt, W.; Hoffmann, T.; Schilling, S.; Demuth, H.-U.; Heiser, U.; Optimization of inhibitors for human glutaminyl cyclase by structure based design and bio-isosteric replacement Drug. Future 34, 186, (2009)

Buchholz, M.; Hamann, A.; Aust, S.; Brandt, W.; Böhme, L.; Hoffmann, T.; Schilling, S.; Demuth, H.-U.; Heiser, U.; Inhibitors for Human Glutaminyl Cyclase by Structure Based Design and Bioisosteric Replacement J. Med. Chem. 52, 7069-7080, (2009) DOI: 10.1021/jm900969p

Brandt, W.; Bräuer, L.; Günnewich, N.; Kufka, J.; Rausch, F.; Schulze, D.; Schulze, E.; Weber, R.; Zakharova, S.; Wessjohann, L.; Molecular and structural basis of metabolic diversity mediated by prenyldiphosphate converting enzymes Phytochemistry 70, 1758-1775, (2009) DOI: 10.1016/j.phytochem.2009.09.001

Biastoff, S.; Brandt, W.; Dräger, B.; Putrescine N-methyltransferase – The start for alkaloids Phytochemistry 70, 1708-1718, (2009) DOI: 10.1016/j.phytochem.2009.06.012

Biastoff, S.; Reinhardt, N.; Reva, V.; Brandt, W.; Dräger, B.; Evolution of putrescine N-methyltransferase from spermidine synthase demanded alterations in substrate binding FEBS Lett. 583, 3367-3374, (2009) DOI: 10.1016/j.febslet.2009.09.043

Burse, A.; Frick, S.; Schmidt, A.; Buechler, R.; Kunert, M.; Gershenzon, J.; Brandt, W.; Boland, W.; Implication of HMGR in homeostasis of sequestered and de novo produced precursors of the iridoid biosynthesis in leaf beetle larvae Insect Biochem. Mol. Biol. 38, 76-88, (2008) DOI: 10.1016/j.ibmb.2007.09.006

Brock, A.; Brandt, W.; Dräger, B.; The functional divergence of short-chain dehydrogenases involved in tropinone reduction Plant J. 54, 388-401, (2008) DOI: 10.1111/j.1365-313X.2008.03422.x

Bräuer, L.; Brandt, W.; Schulze, D.; Zakharova, S.; Wessjohann, L.; A Structural Model of the Membrane-Bound Aromatic Prenyltransferase UbiA from E. coli ChemBioChem 9, 982-992, (2008) DOI: 10.1002/cbic.200700575

Stehle, F.; Brandt, W.; Schmidt, J.; Milkowski, C.; Strack, D.; Activities of Arabidopsis sinapoylglucose:malate sinapoyltransferase shed light on functional diversification of serine carboxypeptidase-like acyltransferases Phytochemistry 69, 1826-1831, (2008) DOI: 10.1016/j.phytochem.2008.03.021

Schullehner, K.; Dick, R.; Vitzthum, F.; Schwab, W.; Brandt, W.; Frey, M.; Gierl, A.; Benzoxazinoid biosynthesis in dicot plants Phytochemistry 69, 2668-2677, (2008) DOI: 10.1016/j.phytochem.2008.08.023

Wrenger, S.; Faust, J.; Mrestani-Klaus, C.; Brandt, W.; Thielitz, A.; Neubert, K.; Reinhold, D.; Non-substrate peptides influencing dipeptidyl peptidase IV/CD26 activity and immune cell function Front. Biosci. Volume, 3194, (2008) DOI: 10.2741/2920

Kopycki, J. G.; Stubbs, M. T.; Brandt, W.; Hagemann, M.; Porzel, A.; Schmidt, J.; Schliemann, W.; Zenk, M. H.; Vogt, T.; Functional and Structural Characterization of a Cation-dependent O-Methyltransferase from the Cyanobacterium Synechocystis sp. Strain PCC 6803 J. Biol. Chem. 283, 20888-20896, (2008) DOI: 10.1074/jbc.M801943200

Klein, R.; Brandt, W.; Fast access to total energies Chem. Cent. J. 2, P35, (2008) DOI: 10.1186/1752-153X-2-S1-P35

Heintz, T.; Brandt, W.; Weber, L.; Wessjohann, L. A.; Comparing Natural Product (NP) and non-NP datasets at an atomic scale Chem. Cent. J. 2, P25, (2008) DOI: 10.1186/1752-153X-2-S1-P25

Freydank, A.-C.; Brandt, W.; Dräger, B.; Protein structure modeling indicates hexahistidine-tag interference with enzyme activity Proteins 72, 173-183, (2008) DOI: 10.1002/prot.21905

Geissler, R.; Brandt, W.; Ziegler, J.; Molecular Modeling and Site-Directed Mutagenesis Reveal the Benzylisoquinoline Binding Site of the Short-Chain Dehydrogenase/Reductase Salutaridine Reductase Plant Physiol. 143, 1493-1503, (2007) DOI: 10.1104/pp.106.095166

Jelić, D.; Mildner, B.; Koštrun, S.; Nujić, K.; Verbanac, D.; Čulić, O.; Antolović, R.; Brandt, W.; Homology Modeling of Human Fyn Kinase Structure: Discovery of Rosmarinic Acid as a New Fyn Kinase Inhibitor and in Silico Study of Its Possible Binding Modes J. Med. Chem. 50, 1090-1100, (2007) DOI: 10.1021/jm0607202

Hinneburg, A.; Egert, B.; Porzel, A.; Duplicate detection of 2D-NMR Spectra J. Integr. Bioinformatics 4, 64-80, (2007) DOI: 10.1515/jib-2007-53

Wessjohann, L. A.; Schneider, A.; Abbas, M.; Brandt, W.; Selenium in chemistry and biochemistry in comparison to sulfur Biol. Chem. 388, 997-1006, (2007) DOI: 10.1515/BC.2007.138

Teuber, M.; Azemi, M. E.; Namjoyan, F.; Meier, A.-C.; Wodak, A.; Brandt, W.; Dräger, B.; Putrescine N-methyltransferases—a structure–function analysis Plant Mol. Biol. 63, 787-801, (2007) DOI: 10.1007/s11103-006-9126-7

Stehle, F.; Brandt, W.; Milkowski, C.; Strack, D.; Corrigendum to “Structure determinants and substrate recognition of serine carboxypeptidase-like acyltransferases from plant secondary metabolism” [FEBS Lett. 580 (2006) 6366-6374] FEBS Lett. 581, 164-165, (2007) DOI: 10.1016/j.febslet.2006.12.001

Hinneburg, A.; Gabriel, H.-H.; Gohr, A.; Bayesian Folding-In with Dirichlet Kernels for PLSI (2007) DOI: 10.1109/ICDM.2007.15

Hinneburg, A.; Porzel, A.; Wolfram, K.; An Evaluation of Text Retrieval Methods for Similarity Search of Multi-dimensional NMR-Spectra Lecture Notes in Computer Science 4414, 424-438, (2007) ISBN: 978-3-540-71233-6 DOI: 10.1007/978-3-540-71233-6_33

Stehle, F.; Brandt, W.; Milkowski, C.; Strack, D.; Structure determinants and substrate recognition of serine carboxypeptidase-like acyltransferases from plant secondary metabolism FEBS Lett. 580, 6366-6374, (2006) DOI: 10.1016/j.febslet.2006.10.046

Selent, J.; Brandt, W.; Pamperin, D.; Göber, B.; Enantiomeric N-methyl-4-piperidyl benzilates as muscarinic receptor ligands: Radioligand binding studies and docking studies to models of the three muscarinic receptors M1, M2 and M3 Bioorg. Med. Chem. 14, 1729-1736, (2006) DOI: 10.1016/j.bmc.2005.10.030

Gromer, S.; Wessjohann, L. A.; Eubel, J.; Brandt, W.; Mutational Studies Confirm the Catalytic Triad in the Human Selenoenzyme Thioredoxin Reductase Predicted by Molecular Modeling ChemBioChem 7, 1649-1652, (2006) DOI: 10.1002/cbic.200600080

Reiss, E.; Schlesier, B.; Brandt, W.; cDNA sequences, MALDI-TOF analyses, and molecular modelling of barley PR-5 proteins Phytochemistry 67, 1856-1864, (2006) DOI: 10.1016/j.phytochem.2006.06.014

Barth, A.; Thondorf, I.; Gebauer, S.; Brandt, W.; Neubert, K.; Stano, J.; Psenak, M.; Kovacs, P.; Gedanken zum Mechanismus der Serinproteasen, Teil II–Dipeptidyl-Peptidase IV (DP IV/CD 26) Acta Fac. Pharm. Univ. Comen. 52, 7-21, (2005)

Wessjohann, L. A.; Ruijter, E.; Garcia-Rivera, D.; Brandt, W.; What can a chemist learn from nature’s macrocycles? – A brief, conceptual view Mol. Divers. 9, 171-186, (2005) DOI: 10.1007/s11030-005-1314-x

Lipka, V.; Dittgen, J.; Bednarek, P.; Bhat, R.; Wiermer, M.; Stein, M.; Landtag, J.; Brandt, W.; Rosahl, S.; Scheel, D.; Llorente, F.; Molina, A.; Parker, J.; Somerville, S.; Schulze-Lefert, P.; Pre- and Postinvasion Defenses Both Contribute to Nonhost Resistance in Arabidopsis Science 310, 1180-1183, (2005) DOI: 10.1126/science.1119409

Hans, J.; Brandt, W.; Vogt, T.; Site-directed mutagenesis and protein 3D-homology modelling suggest a catalytic mechanism for UDP-glucose-dependent betanidin 5-O-glucosyltransferase from Dorotheanthus bellidiformis Plant J. 39, 319-333, (2004) DOI: 10.1111/j.1365-313X.2004.02133.x

Bräuer, L.; Brandt, W.; Wessjohann, L. A.; Modeling the E. coli 4-hydroxybenzoic acid oligoprenyltransferase (ubiA transferase) and characterization of potential active sites J. Mol. Model. 10, 317-327, (2004) DOI: 10.1007/s00894-004-0197-6

Brandt, W.; Dessoy, M. A.; Fulhorst, M.; Gao, W.; Zenk, M. H.; Wessjohann, L. A.; A Proposed Mechanism for the Reductive Ring Opening of the Cyclodiphosphate MEcPP, a Crucial Transformation in the New DXP/MEP Pathway to Isoprenoids Based on Modeling Studies and Feeding Experiments ChemBioChem 5, 311-323, (2004) DOI: 10.1002/cbic.200300743

Mrestani-Klaus, C.; Brandt, W.; Faust, J.; Wrenger, S.; Reinhold, D.; Ansorge, S.; Neubert, K.; New Results on the Conformations of Potent DP IV (CD26) Inhibitors bearing the N-terminal MWP Structural Motif Adv. Exp. Med. Biol. 524, 65-68, (2004) DOI: 10.1007/0-306-47920-6_7

Kühn-Wache, K.; Hoffmann, T.; Manhart, S.; Brandt, W.; Demuth, H.-U.; The Specificity of DP IV for Natural Substrates is Peptide Structure Determined Adv. Exp. Med. Biol. 524, 57-63, (2004) DOI: 10.1007/0-306-47920-6_6

Holzgrabe, U.; Brandt, W.; Mechanism of Action of the Diazabicyclononanone-type κ-Agonists J. Med. Chem. 46, 1383-1389, (2003) DOI: 10.1021/jm0210360

Black, S. L.; Jales, A. R.; Brandt, W.; Lewis, J. W.; Husbands, S. M.; The Role of the Side Chain in Determining Relative δ- and κ-Affinity in C5‘-Substituted Analogues of Naltrindole J. Med. Chem. 46, 314-317, (2003) DOI: 10.1021/jm020997b

Wessjohann, L. A.; Brandt, W.; Thiemann, T.; Biosynthesis and Metabolism of Cyclopropane Rings in Natural Compounds Chem. Rev. 103, 1625-1648, (2003) DOI: 10.1021/cr0100188

Schütz, J.; Brandt, W.; Spetea, M.; Wurst, K.; Wunder, G.; Schmidhammer, H.; Synthesis of 6-Amino Acid Substituted Derivatives of the Highly Potent Analgesic 14-O-Methyloxymorphone Helv. Chim. Acta 86, 2142-2148, (2003) DOI: 10.1002/hlca.200390171

Lorey, S.; Stöckel-Maschek, A.; Faust, J.; Brandt, W.; Stiebitz, B.; Gorrell, M. D.; Kähne, T.; Mrestani-Klaus, C.; Wrenger, S.; Reinhold, D.; Ansorge, S.; Neubert, K.; Different modes of dipeptidyl peptidase IV (CD26) inhibition by oligopeptides derived from the N-terminus of HIV-1 Tat indicate at least two inhibitor binding sites Eur. J. Biochem. 270, 2147-2156, (2003) DOI: 10.1046/j.1432-1033.2003.03568.x