TY - JOUR ID - 1107 TI - Auxin-induced degradation dynamics set the pace for lateral root development JO - Development PY - 2015 SP - 905-909 AU - Guseman, J. M. AU - Hellmuth, A. AU - Lanctot, A. AU - Feldman, T. P. AU - Moss, B. L. AU - Klavins, E. AU - Calderón Villalobos, L. I. A. AU - Nemhauser, J. L. AU - VL - 142 UR - DO - 10.1242/dev.117234 AB - Auxin elicits diverse cell behaviors through a simple nuclear signaling pathway initiated by degradation of Aux/IAA co-repressors. Our previous work revealed that members of the large Arabidopsis Aux/IAA family exhibit a range of degradation rates in synthetic contexts. However, it remained an unresolved issue whether differences in Aux/IAA turnover rates played a significant role in plant responses to auxin. Here, we use the well-established model of lateral root development to directly test the hypothesis that the rate of auxin-induced Aux/IAA turnover sets the pace for auxin-regulated developmental events. We did this by generating transgenic plants expressing degradation rate variants of IAA14, a crucial determinant of lateral root initiation. Progression through the well-established stages of lateral root development was strongly correlated with the engineered rates of IAA14 turnover, leading to the conclusion that Aux/IAAs are auxin-initiated timers that synchronize developmental transitions. A2 - C1 - Molecular Signal Processing ER -