TY - JOUR ID - 894 TI - Rothtalazepane, A New Azepane from the Wood of Rothmannia talbotii (Rubiaceae) JO - Nat. Prod. Commun. PY - 2017 SP - 1435-1436 AU - Koagne, R. R. AU - Bitchagno, G. T. M. AU - Fobofou, S. A. T. AU - Konga, I. S. AU - Tamokou, J. d. D. AU - Wessjohann, L. A. AU - Tane, P. AU - VL - 12 UR - DO - 10.1177/1934578X1701200912 AB - Rothmannia talbotii, a hitherto chemically unexplored medicinal plant, is used in the Western Region of Cameroon to relieve fever. In our ongoing search for bioactive compounds from Cameroonian medicinal plants, a previously undescribed compound rothtalazepane (1), along with six known compounds, aitchisonide B (2), D-mannitol (3), β-D-glucopyranosyl-(6→1’)-β-D-glucopyranoside (4), monopalmitin (5), stigmasterol (6), and sitosterol 3-O-β-D-glucopyranoside (7) were isolated and characterized from the crude ethanol extract of the wood of R. talbotii. Rothtalazepane (1) exhibits no significant activity against several microbial strains, thus its function likely lies not in antimicrobial defense and it is not the active principle against urinary infections described for Rothmannia. A2 - C1 - Bioorganic Chemistry ER -