@Article{IPB-2075,
author = {Black, S. L. and Jales, A. R. and Brandt, W. and Lewis, J. W. and Husbands, S. M.},
title = {{The Role of the Side Chain in Determining Relative δ- and κ-Affinity in C5‘-Substituted Analogues of Naltrindole}},
year = {2003},
pages = {314-317},
journal = {J. Med. Chem.},
doi = {10.1021/jm020997b},
volume = {46},
abstract = {The role of the side chain in 5‘-substituted analogues of naltrindole has been further explored with the synthesis of series of amides, amidines, and ureas. Amidines (8, 13) had greatest selectivity for the κ receptor, as predicted from consideration of the message-address concept. It was also found that an appropriately located carbonyl group, in ureas (10) and amides (7), led to retention of affinity and antagonist potency at the δ receptor.}    
}