Publications - Bioorganic Chemistry
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Displaying results 1 to 3 of 3.
Wessjohann, L.; The First Total Syntheses of Taxol Angew. Chem. Int. Ed. 33, 959-961, (1994) DOI: 10.1002/anie.199409591
A milestone in natural product chemistry is the first total synthesis of taxol achieved independently of each other by the groups of R. A. Holton and K. C. Nicolaou. Taxol is at present the most promising anti‐cancer agent, and its synthesis is extremely demanding. It is highly unlikely that this climax will be the end of probably the greatest worldwide effort yet to synthesize a single compound.
Wessjohann, L.; Die ersten Totalsynthesen von Taxol Angew. Chem. 106, 1011-1013, (1994) DOI: 10.1002/ange.19941060906
Ein Meilenstein der Naturstoffchemie ist die Totalsynthese des zur Zeit vielversprechendsten und synthetisch extrem anspruchsvollen Antikrebsmittels Taxol, die unabhängig voneinander den Arbeitsgruppen von R.A. Holton und K.C. Nicolaou gelang. Mit diesem vorläufigen Höhepunkt dürfte der vermutlich weltweit größte Aufwand zur Totalsynthese einer Einzelverbindung jedoch nicht beendet sein.
Baumert, A.; Maier, W.; Matern, U.; Schmidt, J.; Schumann, B.; Gröger, D.; Acridone Alkaloids from Cell Suspension Cultures of Thamnosma montana Planta Med. 60, 143-145, (1994) DOI: 10.1055/s-2006-959437
Cell Suspension cultures of Thamnosma montana were grown in Gamborg B5 medium which was best suited for acridone alkaloid formation. From the lyophilized cell material nine acridones and three acridone-monoglucosides have been isolated which were found for the first time in the genus Thamnosma. Moreover, N-methylacridone which is known from the intact plant was found. Gravacridonol monoglucoside was identified as a new alkaloid. Interestingly, most isolated alkaloids belong to the dihydrofuroacridones.
