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05.09.2017

Protein Specialists Meet in Halle (Germany)

Photo: Markus Scholz/ScienceCampus Halle

Between September 11 and 13, 2017, scientists from all parts of the world will meet at the Leibniz Institute of Plant Biochemistry in Halle/Saale (Germany). They will discuss the fate of proteins. The conference titled N-term 2017 – Proteostasis via the N-terminus beckons about 100 specialists from the animal and plant-related sciences as well as from medicine and biotechnology. While their specialties vary widely, the scientists are all eager to share their expertise and interest in the umbrella topic 'Protein Homeostasis or Proteostasis'.

Proteostasis is the term for the equilibrium of proteins in organisms. As enzymes, proteins control all physiological processes such as respiration, digestion, development and immune response in living organisms. In order to ensure the proper interactions of all proteins, the enzymes must always work with the right activity at the proper time and location. Therefore, proteins are subject to continuous biosynthesis and degradation. Proteins are synthesized as needed. Once they have fulfilled their biological function, they will be inactivated and degraded. The cell recognizes and disposes of misfolded, damaged or no longer functional proteins. The protein itself determines its own natural half-life. This natural life-span information is located at the protein's amino terminal. The N-terminal stretch of the protein sequence determines the fate and life-span of the entire protein. Malfunctions in the intricately regulated protein equilibrium cause many serious diseases in humans, animals and plants.

Under the umbrella of the proteostasis topic, the scientists will gather at the N-Term 2017 to discuss neurodegenerative disease and new therapies for hepatocellular carcinoma as well as stress reactions of plants to oxygen deficiency or disease. In any case, new perspectives, approaches and possibly even solutions will emerge from this concoction of converging expertise.

For further information about the program see here.

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