Publikationen

• Buchholz, M., Hamann, A., Aust, S., Brandt, W., Bohme, L., Hoffmann, T., Schilling, S., Demuth, H.U. & Heiser, U. Inhibitors for human glutaminyl cyclase by strucure based design and bioisosteric replacement. J. Med. Chem. 52, 7069-7080 (2009)

• Pienkny, S., Brandt, W., Kramell, R. & Ziegler, J. Functional characterization of a novel benzylisoquinoline O-Methyltransferase suggests its involvement in Papaverine biosynthesis in Opium Poppy (P. somniferum L.). Plant J. 60, 56-67 (2009)

• Stehle, F., Brandt, W., Stubbs, M.T., Milkowski, C. & Strack, D. Sinapoyltransferases in the light of molecular evolution. Phytochemistry. 70, 1652-1662 (2009)

• Ziegler, J., Brandt, W., Geißler, R. & Facchini, P.J. Removal of substrate inhibition and increase in maximal velocity in the short chain dehydrogenase/ reductase salutaridine involved in morphine biosynthesis. J. Biol. Chem. 284, 26758-26767 (2009)

• Ziegler, J., Facchini, P.J., Geißler, R., Schmidt, J., Ammer, C., Kramell, R., Voigtländer, S., Gesell, A., Pienkny, S. & Brandt, W. Evolution of morphine biosynthesis in opium poppy. Phytochemistry. 79, 1969-1707 (2009)

• Brock, A., Brandt, W. & Dräger, B. The functional divergence of short-chain dehydrogenases involved in tropinone reduction. Plant J. 54, 388-401 (2008)

• Bräuer, L., Brandt, W., Schulze, D., Zakharova, S. & Wessjohann, L. A structural model of the membrane-bound aromatic prenyltransferase UbiA from E. coli. ChemBioChem. 9, 982-992 (2008)

• Burse, A., Frick, S., Schmidt, A., Buechler, R., Kunert, M., Gershenzon, J., Brandt, W. & Boland, W. Implication of HMGR in homestasis of sequestered and de novo produced precursors of the iridoid biosynthesis in leaf beetle larvae. Insect Biochem. Mol. Biol. 38, 76-88 (2008)

• Freydank, A.C., Brandt, W. & Dräger, B. Protein structure modeling indicates hexahistidine-tag interference with enzyme activity. Proteins. 173-183 (2008)

• Heintz, T., Brandt, W., Weber, L. & Wessjohann, L.A. Comparing Natural Product (NP) and non-NP datsets at an atomic scale. Chemistry Central Journal. (2008)

• Klein, R. & Brandt, W. Fast access to total energies. Chemistry Central Journal. (2008)

• Kopycki, J. G., Stubbs, M. T. , Brandt, W., Hagemann, M., Porzel, A., Schmidt, J., Schliemann, W., Zenk, M. H. & Vogt, T. Functional and structural characterization of a cation-dependent O-methyltransferase from the cyanobacterium Synechocystis sp. strain pcc 6803. J. Biol. Chem. 283, 20888-20896 (2008)

• Stehle, F., Brandt, W., Schmidt, J., Mikowski, C. & Strack, D. Activities of arabidopsis sinapoyltransferase shed light on functional diversification of serine carboxypeptidase-like acyltransferases. Phytochemistry. 69, 1826-1831 (2008)

• Wrenger, S., Faust, J., Mrestani-Klaus, C., Brandt, W., Thielitz, A., Neubert, K. & Reinhold, D. Non-substrate peptides influencing dipeptidyl peptidase IV/CD26 activity and immune cell function. Front. Biocsience. 13, 3194-3201 (2008)

• Bräuer, L., Wessjohann, L. A. & Brandt, W. Modeling of a cannabis sativa terpene synthase. Protein Data Bank, entry 2DK0. (2007)

• Geissler, R., Brandt, W. & Ziegler, J. Molecular Modeling and Site-Directed Mutagenesis Reveal the Benzylisoquinoline Binding site of the Short-Chain Dehydrogenase/Ruductase Salutaridine Reductase . Plant Physiol. 143, 1493-1503 (2007)

• Hinneburg, A., Egert, B. & Porzel, A. Duplicate detection of 2D-NMR spectra. J. Integrat. Bioinform. 4, 53 (2007)

• Hinneburg, A., Gabriel, H.-H. & Gohr, A. Bayesian foling in with dirichlet kernels for PLSI. Seventh IEEE International Conference on Data Mining, DOI: 10.1109/ICDM.2007.15. (2007)

• Hinneburg, A., Porzel, A. & Wolfram, K. An evaluation of text retrieval methods for similarity search of multi-dimensional NMR-spectra. Lernen, Wissen, Adaption, Workshop Proceedings. 282-289 (2007) ISBN:978-3-86010-907-6

• Jelic, D., Mildner, B., Kostrun, S., Jujic, K., Verbanac, D., Culic, O., Antolovic, R. & Brandt, W. Homology Modeling of Human Fyn Kinase Structure: Discovery of Rosmarinic Acid as a New Fyn Kinase Inhibitor and in Silico Study of Its Possible Binding Modes . J. Med. Chem. 50, 1090-1100 (2007)

• Stehle, F., Brand, W., Mikowski, C. & Strack, D. Structure determinants and substrate recognition of serine carboxypeptidase-like acyltransferases from plant secondary metabolism. FEBS Letters. 581, 164-165 (2007)

• Teuber, M., Azemi, M. E., Namyoan, F., Meier, A.-C., Wodak, A., Brandt, W. & Dräger, B. Putrescine N-methyltransferases - a structure-function analysis. Plant. Mol. Biol. 787-801 (2007)

• Gromer, S., Wessjohann, L.A., Eubel, J. & Brandt, W. Mutational Studies Confirm the Catalytic Triad in the Human Selenoenzyme Thioredoxin Reductase Predicted by Molecular Modeling. ChemBioChem. 7, 1649-1652 (2006)

• Reiss, E., Schlesier, B. & Brandt, W. cDNA sequences, MALDI-TOF analysis, and molecular modelling of barley PR-5 protein. Phytochemistry. 67, 1856-1864 (2006)

• Selent, J., Brandt, W., Pamperin, D. & Göber, B. Enantiomeric N-methyl-4-piperidyl benzilates as muscarinic receptor ligands: Radioligand binding studies and docking studies to models of three muscarinic receptors M1, M2 and M3. Bioorganic & Medicinal Chemistry. 14, 1729-1736 (2006)

• Stehle, F., Brandt, W., Milkowski, C. & Strack, D. Structure determinants and substrate recognition of serine carboxypeptidase-like acyltransferases from plant secondary metabolism. FEBS Lett. 580, 6366-6374 (2006)

• Barth, A, Thondorf, I. , Gebauer, S, Brandt, W., Neubert, K., Stano, J., Psenak, M. & Kovacs, P. Gedanken zum Mechanismus der Serinproteasen Teil 2. Dipeptidyl Peptidase IV (DP IV/CD 26). Acta Facultatis Pharmaceuticae Universitatis Comenianae. LII, 7-20 (2005)

• Lipka, V., Dittgen, J. , Bednarek, P., Bhat, R., Wiermer, M., Stein, M., Landtag, J., Brandt, W., Rosahl, S., Scheel, D., Llorente, F. , Molina, A., Parker, J., Somerville, S. & Schulze-Lefert, P. Pre- and postinvasion defenses both contribute to nonhost resistance in Arabidopsis. Science. 310 (5751), 1180-1183 (2005)

• Wessjohann, L. A., Ruijter, E., Garcia-Rivera, D. & Brandt, W. What can a chemist learn from nature's macrocycles?--a brief, conceptual view. Mol Divers. 9 (1-3), 171-186 (2005)

• Bräuer L., Brandt W. & Wessjohann, L.A. Modeling of the E. coli – 4-hydroxybenzoic acid oligoprenyl-transferase (ubiA-transferase) and characterization of potential active sites. J. Mol. Mod. 10, 317-327 (2004)

• Brandt, W., Dessoy, M.A., Fulhorst, M., Gao, W., Zenk, M.H. & Wessjohann, L.A. A Mechanism Proposal for the Reductive Ring Opening of the Cyclodiphosphate MEcPP, a Crucial Transformation in the New DXP/MEP-Pathway to Isoprenoids Based on Modeling Studies and Feeding Experiments. ChemBiochem. 5(3), 311-323 (2004)

• Hans, J., Brandt, W. & Vogt, T. Site-directed mutagenesis and protein 3D-homology modelling suggest a catalytic mechanism for UDP-glucose dependent betanidin 5-O-glucosyl-transferase from Dorotheanthus bellidiformis. Plant J. 39, 319-333 (2004)

• Black, S.L., Jales, A.R., Brandt, W., Lewis, J.W. & Husbands, S.M. The role of the side chain in determining relative delta- and kappa-affinity in C5’-substituted analogues of naltrindole. J Med Chem. 46(2), 314-317 (2003)

• Holzgrabe, U. & Brandt, W. Mechanism of Action of the Diazabicyclononanone-type Kappa-Agonists. J Med Chem. 46(8), 1383-1389 (2003)

• Kuhn-Wache, K., Hoffmann, T., Manhart, S., Brandt, W. & Demuth, H.U. The specificity of DP IV for natural substrates is peptide structure determined. Dipeptidyl Aminopeptidases in Health and Disease. (Hildebrandt, M., Klapp, B.F., Hoffmann, T. & Demuth, H.-U., eds.) Adv. Exp. Med. Biol., Kluwer Academic/Plenum Publishers. Vol 524, 57-63 (2003)

• Lorey, S., Stockel-Maschek, A., Faust, J., Brandt, W., Stiebitz, B., Gorrell, M.D., Kahne, T., Mrestani-Klaus, C., Wrenger, S., Reinhold, D., Ansorge, S. & Neubert, K. Different modes of dipeptidyl peptidase IV (CD26) inhibition by oligopeptides derived from the N-terminus of HIV-1 Tat indicate at least two inhibitor binding sites. Eur J Biochem. 270(10), 2147-56 (2003)

• Mrestani-Klaus, C., Brandt, W., Faust, J., Wrenger, S., Reinhold. D., Ansorge, S. & Neubert, K. New results on the conformations of potent DP IV (CD26) inhibitors bearing the N-terminal MWP structural motif, Dipeptidyl Aminopeptidases in Health and Disease. (Hildebrandt, M., Klapp, B.F., HoffmannT. & Demuth, H.-U., eds.) Adv. Exp. Med. Biol., Kluwer Academic/Plenum Publishers. Vol 524, 65-68 (2003)

• Schütz, J., Brandt, W., Spetea, M., Wurst, K., Wunder, G. & Schmidhammer, H. Synthesis of 6-Amino Acid Substituted Derivatives of the Highly Potent Analgesic 14-O-Methyloxymorphone. Helv. Chim. Acta. 86, 2142-2148 (2003)

• Schütz, J., Brandt, W., Spetea, M., Wurst, K., Wunder, G. & Schmidhammer, H. Synthesis of 6-Amino Acid Substituted Derivatives of the Highly Potent Analgesic 14-O-Methyloxymorphone. Helv. Chim. Acta. 86, 2709 (2003)

• Wessjohann, L.A., Brandt, W. & Thiemann, T. Biosynthesis and Metabolism of Cyclopropane-Rings in Natural Compounds. Chem Rev 2003. 103, 1625-1647 (2003)